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. 2022 Jan 6;20:24. doi: 10.1186/s12951-021-01232-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — a Schematic illustration of PEG-RIe-AuNPs and multiple images of sentinel lymph nodes in vivo. b PET/CLI signal of PEG-RIe-AuNPs accumulate in sentinel lymph nodes over time. Detailed: (upper) 3D-PET/CT images, (middle) PET/CT images of cross-sectional, (bottom) CLI images. Reprinted with permission [89]. Copyright 2016, Wiley–VCH Verlag GmbH & Co. KGaA, Weinheim. c Self-assembly and modification of transferrin encapsulated GdF₃ nanoparticles and TEM images. Scale bars are 100 nm (TEM) and 1 nm (HRTEM). d T₁ and T₂-weighted MRI images of SLNs in healthy mouse after injection of GdF₃@Tf NPs 3 h. e Multimodal imaging of colorectal tumor bearing-mice at different time points after intravenous injection of ⁶⁴Cu-GdF₃@Tf-Cy7 NPs. Reproduced from [90]. Copyright 2020, American Chemical Society