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. 2021 Dec 24;9:793428. doi: 10.3389/fcell.2021.793428

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Copyright © 2021 Huo, Zhang, Huang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulation of glycolysis and gluconeogenesis enzymes by epigenetic modifications. Epigenetic regulatory enzymes, lncRNA, and circRNA regulate the epigenetic regulation of the key proteins, GLUT1, HK2, PKM, ENO2, LDHA, IDH, and the key enzymes FBP and PCK in the process of gluconeogenesis. GLUT1, glucose transporter type 1; HK2, hexokinase 2; PKM, pyruvate kinase M1/2; ENO2, enolase 2; LDHA, lactate dehydrogenase A; IDH, isocitrate dehydrogenase (NADP (+)); FBP, fructose-bisphosphatase; PCK, phosphoenolpyruvate carboxykinase.