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Chromatin modification by metabolites. Metabolites produced from cellular metabolic pathways are used as substrates for DNA, RNA, and chromatin modification. Moreover, the intracellular pools of metabolites can modulate the activity of chromatin-modifying enzymes. TCA, tricarboxylic acid; αKG, α-ketoglutarate; SucCoA, succinyl-CoA; PAR, poly (ADP–ribose); GlcNAc, β-N-acetylglucosamine; SAH, S-adenosylhomocysteine; SAM, S-adenosylmethionine.
