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Inter-organ cross-talk in the pathogenesis of metabolic dysfunction in people with obesity. CO2 = carbon dioxide, HSC = hepatic stellate cell, FFA = free fatty acid, PAI-1 = plasminogen activator inhibitor-1, TG = triglyceride, TGRL = triglyceride-rich lipoprotein, VLDL = very-low-density lipoprotein.
