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(A) Simulated MK-2075 percent olfactory response inhibition over time (median ± 90% CI) at a predicted dose of 50 mg infused intravenously over 8 h in humans. (B) Graphical representation of the simulated olfaction inhibition response (median ± 90% CI) at 7 h after the start of infusion as a function of the simulated plasma concentration of MK-2075 at 7 h after doses of 20, 35, 45, 50, 55, 65, and 80 mg.
