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. 2021 Dec 24;12:786078. doi: 10.3389/fphar.2021.786078

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Copyright © 2021 Ballard, Pall, Vardigan, Zhao, Holahan, Zhou, Jochnowitz, Kraus, Klein, Henze, Houghton, Burgey, Gibson and Struyk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overlay of MK-2075 exposure–response in the mouse tail flick latency and rhesus thermode heat withdrawal assays of nociception using (A) total plasma concentration and (B) unbound plasma concentration normalized by in vitro potency.