TABLE 1.
Comparison of preclinical potency and clinical minimum efficacious concentration (MEC) for SOC analgesics.
| SOC analgesic | Clinical MEC a (µM), mean (range) | Mouse tail flick EC 50 (µM), mean ± SE |
|---|---|---|
| Morphine | 0.074 (0.032–0.116) b | 0.14 ± 0.03 |
| Tramadol | 1.092 (0.077–3.744) c | 1.13 ± 0.08 |
a
MEC is defined as the trough plasma concentration measured just prior to patient-controlled administration of a subsequent dose of analgesic.
b
Clinical Pharmacokinetics 7: 266–279 (1982) (Dahlstrom, Tamsen, Paalzow, & Hartvig, 1982).
c
The Clinical Journal of Pain, 6: 212–220 (1990) (Lehmann, Kratzenberg, Schroederbark, & Horrichshaermeyer, 1990).