TABLE 2.

Correction of MK-2075 in vivo potency for species-specific plasma protein binding and intrinsic NaV1.7 potency.

Species/assay	In vivo EC 50 or IC 50 (µM)	Plasma fraction unbound (f u,p)	In vitro NaV1.7 IC 50 (µM)	$\frac{\text{In Vivo}}{\text{In Vitro}}$ Scalar
Mouse tail flick	217	0.026	3.228	1.75
Rhesus thermode	7.9	0.077	0.257	2.37