TABLE 3.

MK-2075 preclinical PK parameters from two-compartment model fit of concentration–time data in rat, dog, and monkey.

Species	Parameter	Estimate	SE	CV%
Wistar Han rat	V1 (L/kg)	0.072	0.006	8.3
	CL (L/hr/kg)	0.068	0.003	4.5
	V2 (L/kg)	0.066	0.008	12.3
	CLD (L/hr/kg)	0.013	0.002	16.8
Beagle dog	V1 (L/kg)	0.092	0.013	14.4
	CL (L/hr/kg)	0.149	0.009	5.8
	V2 (L/kg)	0.649	0.071	10.9
	CLD (L/hr/kg)	0.197	0.029	14.9
Rhesus monkey	V1 (L/kg)	0.096	0.010	11.0
	CL (L/hr/kg)	0.067	0.003	4.1
	V2 (L/kg)	0.133	0.015	11.6
	CLD (L/hr/kg)	0.073	0.020	26.8