Table 1.

Glycemic worsening in youth and adults defined as an absolute increase of 0.5% in HbA_1c from baseline to M12 and M21

	M12				M21
	No		Yes		No		Yes
	n	%	n	%	n	%	n	%
Youth
G-MET	35	79.5	9	20.5	30	68.2	14	31.8
MET	39	84.8	7	15.2	27	58.7	19	41.3
Total	74	82.2	16	17.8 *	57	63.3	33	36.7 †
Adult
G-MET	64	95.5	3	4.5	53	79.1	14	20.9
MET	57	91.9	5	8.1	51	82.3	11	17.7
LIRA+MET	61	96.8	2	3.2	54	85.7	9	14.3
Placebo	54	85.7	9	14.3	46	73.0	17	27.0
Total	236	92.5	19	7.5	204	80.0	51	20.0

Bold values are statistically significant comparing youth to adults.

^*P = 0.008 youth compared with adults at M12.

^†P = 0.002 youth compared with adults at M21.