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. 2021 Jul 13;44(9):2018–2024. doi: 10.2337/dc21-0464

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© 2021 by the American Diabetes Association

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The association between standardized T2D GRS and traits related to glucose-insulin homeostasis among youth in the EPOCH study. These plots show the β estimates and CIs from linear regression models in the cohort of weighted (left) and unweighted (right) T2D GRS as predictors of five log-transformed traits: fasting glucose, 2-h glucose, HOMA-IR, insulinogenic index, and oral disposition index. Models controlled for age, sex, BMI z score, exposure to in utero maternal diabetes, and five genetic PCs. β estimates are reported per SD increase in GRS.