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. 2021 Jul 13;44(9):2018–2024. doi: 10.2337/dc21-0464

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© 2021 by the American Diabetes Association

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Interactions with T2D GRS in relation to glucose levels. A: This plot shows the β estimates and CIs from linear regression models of log-transformed fasting glucose as a function of a weighted (left) and unweighted (right) T2D GRS stratified by tertile of BMI z score. Models controlled for age, sex, exposure to in utero maternal diabetes, and five genetic PCs. β estimates are reported per SD increase in GRS. B: This plot shows the β estimates and CIs from linear regression models of log-transformed fasting glucose and 2-h glucose as a function of an unweighted T2D GRS among youth exposed and unexposed in utero to maternal diabetes. Models controlled for age, sex, BMI z score, and five genetic PCs. β estimates are reported per SD increase in GRS.