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. 2021 Jun 16;44(9):1948–1960. doi: 10.2337/dc21-0461

Figure 1.

Figure 1

Plasma glucagon concentrations during the hyperglycemic clamps in youth and adults in the three RISE protocols. Pediatric Medication Study: G/M (A) and MET (B) at baseline (red), after 12 months of intervention (blue), and after 3 months of intervention withdrawal (green). Adult Medication Study: G/M (C), MET (D), L+M (E), and PLAC (F) at baseline (red), after 12 months of intervention (blue), and after 3 months of intervention withdrawal (green). Adult Surgery Study: LB (G) and MET (H) at baseline (red) and after 12 months of intervention (blue) and 24 months of intervention (green). Data are displayed as means ± SEM.