Table 2. Risk of cancer death and all-cause mortality in relation to tertiles of composite cognitive score of PROSPER.

	Continuous composite cognitive score (n = 5,683)		Tertiles of composite cognitive score (n = 5,683)
	Continuous	P-value	Highest tertile (n = 1894)	Middle tertile (n = 1895)	Lowest tertile (n = 1894)	P for trend
Cancer Death
Number (%)	202 (3.55)	-	47 (2.48)	66 (3.48)	89 (4.70)	-
Crude model, HR (95%CI)	1.37 (1.15–1.61)	<0.001	1.00 (ref.)	1.43 (0.98–2.08)	2.01 (1.41–2.86)	<0.001
Model 1, HR (95%CI)	1.33 (1.12–1.61)	0.001	1.00 (ref.)	1.40 (0.93–1.98)	1.91 (1.32–2.75)	<0.001
Model 2, HR (95%CI)	1.27 (1.04–1.54)	0.018	1.00 (ref.)	1.46 (0.98–2.18)	1.65 (1.11–2.47)	0.016
All-cause Mortality
Number (%)	589 (10.36)	-	121 (6.39)	194 (10.24)	274 (14.47)	-
Crude model, HR (95%CI)	1.56 (1.43–1.72)	<0.001	1:00 (ref.)	1.64 (1.31–2.06)	2.42 (1.94–2.99)	<0.001
Model 1, HR (95%CI)	1.45 (1.32–1.61)	<0.001	1:00 (ref.)	1.50 (1.19–1.89)	2.06 (1.65–2.57)	<0.001
Model 2, HR (95%CI)	1.35 (1.22–1.52)	<0.001	1:00 (ref.)	1.52 (1.19–1.93)	1.85 (1.46–2.34)	<0.001

Abbreviations: n: number; HR: Hazard Ratio; CI: Confidence Interval

Model 1: adjusted for age, sex, education and country. Model 2: model 1 further adjusted for body mass index, smoking, alcohol intake, total cholesterol, apolipoprotein E4, systolic blood pressure, antihypertensive treatment, statin treatment, history of diabetes mellitus, history of vascular diseases.