Skip to main content
PMC home page
Acta Veterinaria Scandinavica logoLink to Acta Veterinaria Scandinavica
. 1965 Dec 15;6(1):287–298. doi: 10.1186/BF03547086

Distribution of Selenium in Mice Studied by Whole-Body Autoradiography After Injection of Se75-Sodium Selenite

Die Verteilung von Selenium bei Mäusen auf Grund des Studiums mittels Autoradiographie des ganzen Körpers nach der Injektion von Se75-Natriumselenit

Distribution av selen hos mus studerad med helkroppsautoradiografi efter injektion av Se75-natriumselenit

S O Jacobsson 1,✉, E Hansson 1
PMCID: PMC8741076  PMID: 5858320

Abstract

The distribution in the mouse of Se75 after injection of Se75 sodium selenite was studied by autoradiography of sagittal whole-body sections. The animals were killed at various times, from 5 minutes to 8 days, after a single intravenous injection.

The distribution was characterized by a high blood level of selenium during the whole observation period.

The highest concentration of selenium soon after the injection was found in the liver, heart, kidney and adrenal cortex. Eight days after the injection the highest concentration was seen in the liver and the kidney. The selenium penetrated the placenta, but the uptake was much lower in the fetuses than in the maternal tissue.

Full Text

The Full Text of this article is available as a PDF (1.4 MB).

Footnotes

This investigation was supported by grants from the Swedish Medical Research Council and the Swedish Agricultural Research Council.

References

  1. Buescher R G, Bell M C, Berry R K. The effect of excessive calcium on selenium-75 in swine. J. Animal Sci. 1961;20:368–372. [Google Scholar]
  2. Cousins F B, Cairney I M. Some aspects of selenium metabolism in sheep. Aust. J. agric. Res. 1961;12:927–942. [Google Scholar]
  3. Dudley H C. Toxicology of selenium. I. A study of the distribution of selenium in acute and chronic cases of selenium poisoning. Amer. J. Hyg. 1936;23:169–180. [Google Scholar]
  4. Ekman L, Orstadius K, Åberg B. Distribution of Se75-tagged sodium selenite in pigs with nutritional muscular dystrophy. Acta vet. scand. 1963;4:92–116. [Google Scholar]
  5. Forberg S, Odeblad E, Söre mark R, Uliberg S. Autoradiography with isotopes emitting internal conversion electrons and auger electrons. Acta radiol. (Stockh.) 1964;2:241–262. doi: 10.1080/02841866409134060. [DOI] [PubMed] [Google Scholar]
  6. Grant C A, Thaf velin B. Selenium and hepatosis diaetetica of pigs. Nord. Vet.-Med. 1958;10:657–663. [Google Scholar]
  7. Grant C A, Thaf velin B, Christeil R. Retention of selenium by pig tissues. Acta pharmacol. (Kbh.) 1961;18:285–297. doi: 10.1111/j.1600-0773.1961.tb01670.x. [DOI] [PubMed] [Google Scholar]
  8. Hansson, E.: The formation of pancreatic juice proteins studied with labelled amino acids. Acta physiol. scand. 1959, suppl. 161, 1–99. [PubMed]
  9. Hansson, E. & S.-O. Jacobsson: Uptake of (75Se) selenomethionine in the tissues of the mouse studied by whole-body autoradiography. Biochim. biophys. Acta 1965. In press. [DOI] [PubMed]
  10. Jones G B, Godwin K O. Studies on the nutritional role of selenium. I. The distribution of radioactive selenium in mice. Aust. J. agric. Res. 1963;14:716–723. [Google Scholar]
  11. Kuttler K L, Marble D W, Blincoe C. Serum and tissue residues following selenium injection in sheep. Amer. J. vet. Res. 1961;22:422–428. [PubMed] [Google Scholar]
  12. Lindberg P, Siren M. Selenium concentration in kidneys of normal pigs and pigs affected with nutritional muscular dystrophy and liver dystrophy (hepatosis diaetetica). Life Sci. 1963;5:326–330. doi: 10.1016/0024-3205(63)90164-4. [DOI] [PubMed] [Google Scholar]
  13. Maag D D, Orsborn J S, Clopton J R. The effect of sodium selenite on cattle. Amer. J. vet. Res. 1960;21:1049–1053. [PubMed] [Google Scholar]
  14. McConnell K P. Distribution and excretion studies in the rat after a single subtoxic subcutaneous injection of sodium selenate containing radioselenium. J. biol. Chem. 1941;141:427–437. [Google Scholar]
  15. McConnell K P. Metabolism of selenium in the mammalian organism. J. agric. Fd. Chem. 1963;11:385–388. doi: 10.1021/jf60129a011. [DOI] [Google Scholar]
  16. McConnell K P, Wabnitz C H. Studies on the fixation of radioselenium in proteins. J. biol. Chem. 1957;226:765–776. [PubMed] [Google Scholar]
  17. Miller W T, Williams K T. Minimum lethal dose of selenium as sodium selenite for horses, mules, cattle and swine. J. agric. Res. 1940;60:163–173. [Google Scholar]
  18. Orstadius K, Åberg B. Distribution of Se75-tagged sodium selenite in pigs. Acta vet. scand. 1961;2:60–67. [Google Scholar]
  19. Rosenfeld, I.: Metabolic effects and metabolism of Se in animals. Wyoming agric. Exp. Sta. Bull. 1964, 414, 1–64.
  20. Rosenfeld I O, Beath A. The elimination and distribution of selenium in the tissues in experimental selenium poisoning. J. Nutr. 1945;30:443–449. doi: 10.1093/jn/30.6.443. [DOI] [PubMed] [Google Scholar]
  21. Schulze M O. Selenium and vitamin E. Ann. Rev. Biochem. 1960;29:391–412. doi: 10.1146/annurev.bi.29.070160.002135. [DOI] [PubMed] [Google Scholar]
  22. Schwarz K, Foltz C M. Selenium as an integral part of factor 3 against dietary necrotic liver degeneration. J. Amer. chem. Soc. 1957;79:3292–3293. [PubMed] [Google Scholar]
  23. Smith M I, Westfall B B, Stohlman E F. The elimination of selenium and its distribution in the tissues. Publ. HIth. Rep., Wash. 1937;52:1171–1177. [Google Scholar]
  24. Smith M I, Westfall B B, Stohlman E F. Studies on the fate of selenium in the organism. Publ. Hlth. Rep., Wash. 1938;53:1199–1216. doi: 10.2307/4582598. [DOI] [Google Scholar]
  25. Ullberg, S.: Studies on the distribution and fate of S35-labelled benzylpenicillin in the body. Acta radiol. (Stockh.) 1954, suppl. 118, 1–110. [PubMed]
  26. Ullberg, S.: Autoradiographic studies on the distribution of labelled drugs in the body. Vol. 24, 248. Proceedings of the Second International Conference on the Peaceful Uses of Atomic Energy, Geneva 1958, United Nations, New York 1958.
  27. Westfall B B, Stohlman E F, Smith M I. The placental transmission of selenium. J. Pharmac. exp. Ther. 1938;64:55–57. [Google Scholar]

Articles from Acta Veterinaria Scandinavica are provided here courtesy of BMC

RESOURCES