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Growth inhibitory effects of 4c on macrophage.
| Compound | IC50±SD(nM)a |
Selectivity ratiob | |||
|---|---|---|---|---|---|
| MGC-803 | LO2 | 293T | macrophage | ||
| 4c | 57 ± 6 | 680 ± 220 | 1050 ± 220 | 1210 ± 17 | 11.9 ∼ 21.2 |
| CA-4 | 2 ± 1 | 5 ± 1 | 12 ± 2 | 7 ± 1 | 2.5 ∼ 6.0 |
aEach compound was tested in triplicate; the data are presented as the mean ± SD.
bSelectivity ratio = (IC50 human normal cells)/(IC50 MGC-803).
