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. 2022 Jan 3;14(1):1997296. doi: 10.1080/19490976.2021.1997296

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© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — A comprehensive in silico model of bacterial-produced metabolites and motility interactions. Bacterial-produced metabolites can directly influence gut motility, leading to a cascade of effects and feedback mechanisms impacting the production of the metabolite itself. Gut bacteria replicate and produce their metabolites based on the availability of nutrients. Metabolites impact gut motility, which, in turn, modifies the fluid flow. The flow is directly responsible for the transport and dispersion of nutrients, bacteria, and their metabolites, closing the feedback loop.