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. Author manuscript; available in PMC: 2022 Jan 7.
Published in final edited form as: J Phys Chem B. 2021 Jun 10;125(24):6543–6558. doi: 10.1021/acs.jpcb.1c04473

Figure 3.

Figure 3.

Effect of molecular crowding and excluded volume on microscale-volume viscosity. (a) The excluded volume comprises the space occupied by molecules (green) and the depletion layer surrounding them (gray). (b) Within a crowded solution, two molecules cannot occupy the same space, but their depletion layers can overlap. (c) The viscosity within the depletion layer (ηdl) surrounding a particle is between the pure-buffer (solvent system) viscosity (ηs) and the experimentally measured macroscopic viscosity (ηmacro).108