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. 2022 Jan 3;75:103802. doi: 10.1016/j.ebiom.2021.103802

Figure 4.

Figure 4

Blood levels of adiponectin and IL-1Ra measured in T3cDM and T2DM individuals (Set 3) and associated receiver operator characteristic (ROC) curve analyses. Serum levels of adiponectin (a) and plasma levels of IL-1Ra (b) are significantly elevated in patients with T3cDM (●=PDAC- and ▲=CP-related) compared to those with T2DM (adiponectin: n=33 PDAC-DM, n=15 CP-DM, IL-1Ra: n=28 PDAC-DM, n=15 CP-DM). In combination, serum adiponectin and plasma IL-1Ra achieved an AUC of 0.90 (95% confidence interval (CI): 0.83-0.97) in distinguishing T3cDM from T2DM (n=37 and 30, respectively), with an optimal sensitivity of 83.7% (CI: 68.0-93.8%) and a specificity of 90.0% (CI: 73.5-97.9%) (c). In the distinction of T3cDM from among individuals with NOD (n=37 and 12, respectively), the combined markers achieved an AUC of 0.91 (CI: 0.84-0.99) with optimal sensitivity and specificity of 83.7% (CI: 64.9-92.0%) and 100.0% (CI: 73.6-100.0%), respectively (d). For A and B, the median and interquartile range are shown for each group. T3cDM, type 3c diabetes mellitus; T2DM, type 2 diabetes mellitus; NOD, new-onset diabetes mellitus; AUC, area under the curve.