Table 1.
Characteristics of the Set 2 (Training) and Set 3 (Validation) study cohorts.
| a | Set 2 (n= 137) |
||||||
|---|---|---|---|---|---|---|---|
| PDAC | PDAC-DM | CP | CP-DM | LSDM | Healthy | ||
| Number | 41 | 41 | 10 | 10 | 20 | 15 | |
| Sex | |||||||
| Male | 20 | 25 | 6 | 8 | 11 | 8 | |
| Female | 21 | 16 | 4 | 2 | 9 | 7 | |
| Age, years | |||||||
| Median | 71 | 70 | 46.5 | 55 | 66.5 | 56 | |
| IQR | (62-76) | (65-75) | (44-62.5) | (47.5-63.5) | (60.5-71) | (53-60) | |
| CA19-9, U/mL | |||||||
| Median | 86.9 | 154.6 | 10.1 | 17.1 | 15.4 | 11.5 | |
| IQR | (32.0-290.7) | (44.2-336.3) | (6.1-17.1) | (5.6-49.6) | (10.5-23.5) | (8.2-14.0) | |
| Bilirubin, U/mL | |||||||
| Median | 22 | 21 | 5 | 8 | - | - | |
| IQR | (9-41) | (8-50.5) | (4-6) | (7.3-9.5) | - | - | |
| b | Set 3 (n= 175) |
||||||
|---|---|---|---|---|---|---|---|
| PDAC | PDAC-DM | CP | CP-DM | LSDM | NOD | Healthy | |
| Number | 41 | 37 | 20 | 19 | 20 | 18 | 20 |
| Sex | |||||||
| Male | 22 | 24 | 12 | 9 | 12 | 10 | 8 |
| Female | 19 | 13 | 8 | 10 | 8 | 8 | 12 |
| Age, years | |||||||
| Median | 68 | 71.5 | 49.5 | 52 | 67.5 | 63 | 53 |
| IQR | (60-73) | (63.75.) | (40.5-56) | (46.5-54.5) | (57.5-74) | (58.5-66) | (50-67) |
| CA19-9, U/mL | |||||||
| Median | 181.4 | 271.1 | 15.8 | 24.4 | 47.3 | 19.1 | 10.0 |
| IQR | (70.8-375) | (87.7-426.4) | (8.9-49.2) | (15.3-31.4) | (16.8-61.4) | (10.0-31.2) | (7.0-17.6) |
| Bilirubin, U/mL | |||||||
| Median | 12 | 10 | 4 | 3.5 | - | - | - |
| IQR | (8-39.5) | (6.5-31.5) | (3-6.5) | (3-5) | - | - | - |
| BMI, kg/m2 | |||||||
| Median | 25.5 | 24.2 | 21.9 | 21.7 | 31.6 | 28.4 | 24.9 |
| IQR | (22.2-27.5) | (22.6-27.8) | (19.8-24.3) | (19.1-24.3) | (29.8-37.0) | (23.9-36.5) | (24.3-30.0) |
| AJCC Stage | |||||||
| IA | 1 | 3 | - | - | - | - | - |
| IB | - | - | - | - | - | - | - |
| IIA | 2 | 8 | - | - | - | - | - |
| IIB | 33 | 15 | - | - | - | - | - |
| III | - | - | - | - | - | - | - |
| IV | 3 | 5 | - | - | - | - | - |
PDAC, pancreatic ductal adenocarcinoma; PDAC-DM, pancreatic cancer-associated diabetes; CP, chronic pancreatitis; CP-DM, chronic pancreatitis associated diabetes, DM, long-standing diabetes (>3yr post-diagnosis of DM); NOD, new-onset diabetes (<3yr post-diagnosis of DM); BMI, Body Mass Index; AJCC, American Joint Committee on Cancer.