Figure 4.
Development and validation of 5-predicter model predicting profile at the highest risk for developing asthma, A. Recursive partitioning analysis, Only the derivation cohort (MARC-30 USA) is shown in the tree. The area of the circle is proportional to the log2-transformed size of each branch. The darker orange part in the circle represents the proportion of profile A in each branch. B. Receiver-operating-characteristic curves, To maximize the sum of sensitivity and specificity for all the possible values of the cut-off point, the Youden index method was applied for the following analysis. C. Prediction performance, Overall classification counts and characteristics are shown for both the derivation (MARC-30 USA) and validation (MARC-35 and MARC-30 Finland, separately) cohorts.
Abbreviations: AUC, area under the receiver-operating-characteristic curve; CI, confidence interval; MARC, Multicenter Airway Research Collaboration; NPV; negative predictive value; PPV, positive predictive value; RSV, respiratory syncytial virus.