Table 1.

The Lipinski and Gelovani parameters of the anthranilamides 10–19 calculated with Chemicalize.org program [57]

Cmpd	Molecular formula	Number of atoms	MW	log P	HBD	HBA	MR (cm3 mol−1)	TPSA (Å2)	RBC
1	C27H27ClN4O	60	458.99	5.51	3	4	137.36	66.05	10
2	C25H28Cl2N4O3	62	503.42	5.18	3	5	137.65	92.35	10
3	C25H28BrClN4O3	62	547.88	5.34	3	5	140.47	92.35	10
4	C29H32N4O2	67	468.60	5.16	3	5	143.44	75.28	11
5	C27H33ClN4O4	69	513.04	4.83	3	6	143.73	101.58	11
6	C27H33BrN4O4	69	557.49	5.00	3	6	146.54	101.58	11
7	C27H24N4O	56	420.52	4.73	3	3	128.78	69.81	6
8	C25H25ClN4O3	58	464.95	4.40	3	4	129.07	96.11	6
9	C25H25BrN4O3	58	509.40	4.57	3	4	131.89	96.11	6
10	C27H28N4O	60	424.55	4.90	3	4	132.55	66.05	10
11	C20H22N4O	47	334.423	2.88	3	4	102.45	80.04	7
12	C20H20Cl2N4O	47	403.310	4.09	3	4	112.06	80.04	7
13	C20H20BrClN4O	47	447.760	4.25	3	4	114.88	80.04	7
14	C22H26N4O2	54	378.476	3.14	3	5	113.33	89.27	8
15	C22H25ClN4O2	54	412.920	3.74	3	5	118.13	89.27	8
16	C22H25BrN4O2	54	457.372	3.91	3	5	120.95	89.27	8
17	C20H18N4O	43	330.391	2.71	3	3	98.67	83.80	3
18	C20H17ClN4O	43	364.830	3.31	3	3	103.48	83.80	3
19	C20H17BrN4	43	409.287	3.48	3	3	106.30	83.80	3

MW, molecular weight; log P, partition coefficient; HBD, H-bond donor; HBA, H-bond acceptor; MR, molecular refractivity; TPSA, topological polar surface area; RBC, rotatable bond counts