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. Author manuscript; available in PMC: 2023 Jan 5.
Published in final edited form as: ChemMedChem. 2021 Oct 22;17(1):e202100568. doi: 10.1002/cmdc.202100568

Scheme 1.

Scheme 1.

Synthesis of 2-(thiazol-5-yl)ethan-1-ol derivative 5. Reagents and conditions: a) NBS, THF, RT; b) LDA, THF, 0 °C, then I2, THF, RT; c) potassium vinyltrifuoroborate, iPr2NEt, Pd(dppf)Cl2·CH2Cl2, EtOH, 100 °C; d) LDA, THF, 0 °C, then oxirane, THF, 0–10 °C, then H2O.