Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Synthesis of ANPs 8, the corresponding phosphorodiamidate prodrugs 9, and phosphono disphosphates 10. Reagents and conditions: a) LDA, THF, −20 °C, then oxirane, THF, 10 °C, then TfOCH2P(O)(OiPr)2, −40 °C; b) XPhos Pd G2, R-B(OH)2, K3PO4, THF/H2O (4:1), 40 °C, then TFA, RT, 5 min; c) TMSBr, pyridine, RT, then (L)-NH2CH(Bn)COOiPr·HCl, Aldrithiol™, PPh3, Et3N, pyridine, 70 °C; d) (i) TMSBr, pyridine, RT, (ii) 2M aq. TEAB and TBAH, (iii) CDI, (Bu3N)2P2O7, DMSO.
