Table 2.

Cox regression showing the association between rLTL and incident kidney failure

Variable	Model 1a		Model 2b		Model 3c		Model 4d		Model 5e
	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value
rLTL, ∆∆Ctf	1.21 (1.13, 1.30)	<0.001	1.15 (1.08, 1.23)	<0.001	1.12 (1.05, 1.20)	0.001	1.11 (1.03, 1.19)	0.006	1.11 (1.03, 1.19)	0.007
Age, years			1.04 (1.03, 1.05)	<0.001	1.02 (1.01, 1.03)	<0.001	1.00 (0.99, 1.02)	0.470	1.01 (1.00, 1.02)	0.316
Diabetes duration, years					1.04 (1.03, 1.05)	<0.001	1.01 (1.00, 1.03)	0.125	1.00 (0.99, 1.02)	0.125
BMI, kg/m2					1.01 (0.99, 1.04)	0.171	0.99 (0.97, 1.01)	0.307	0.99 (0.97, 1.01)	0.433
SBP, mmHg					1.02 (1.02, 1.03)	<0.001	1.01 (1.01, 1.02)	<0.001	1.01 (1.01, 1.02)	<0.001
DBP, mmHg					0.98 (0.97, 0.99)	0.001	0.98 (0.97, 0.99)	<0.001	0.98 (0.97, 0.99)	<0.001
HbA1c, mmol/mol							1.01 (1.01, 1.02)	<0.001	1.01 (1.01, 1.02)	<0.001
LDL-C, mmol/l							0.86 (0.78, 0.95)	0.002	0.85 (0.77, 0.93)	0.001
Log10 triacylglycerol							1.38 (0.89, 2.14)	0.147	1.50 (0.96, 2.33)	0.073
HDL-C, mmol/l							1.21 (0.95, 1.54)	0.133	1.22 (0.96, 1.56)	0.102
eGFR, ml min−1 [1.73 m]−2							0.98 (0.97, 0.98)	<0.001	0.98 (0.97, 0.98)	<0.001
Log10 ACR							3.20 (2.80, 3.66)	<0.001	2.92 (2.54, 3.36)	<0.001
Neuropathy									1.20 (0.97, 1.47)	0.089
CVD at baseline									0.88 (0.67, 1.16)	0.356

Sex and retinopathy were included as strata variables

^aModel 1: without adjustment

^bModel 2: adjusted for age and sex

^cModel 3: Model 2 + adjusted for duration of diabetes, BMI, SBP and DBP

^dModel 4: Model 3 + adjusted for HbA_1c, LDL-C, log₁₀ triacylglycerol, HDL-C, eGFR and log₁₀ ACR

^eModel 5: Model 4 + retinopathy, neuropathy and CVD at baseline

^f∆∆Ct refers to each ∆∆Ct decrease in rLTL

DBP, diastolic BP; HDL-C, HDL-cholesterol; LDL-C, LDL-cholesterol; rLTL, relative LTL calculated by negative control (water); SBP, systolic BP