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. 2021 Oct 23;227(1):393–405. doi: 10.1007/s00429-021-02408-3

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© The Author(s) 2021

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Fig. 4 — Summary of mean pairwise distances between each anatomical fiducial (AFID) with significant differences. Bottom right shows heatmap representing the difference between mean pairwise distances between each AFID for OASIS-1 subjects and Parkinson’s disease (PD) patients. Positive differences represent a greater pairwise distance in the OASIS-1 subjects relative to PD patients. Significant differences illustrated in top left of figure, designated by a black box. Significance is determined by Wilcoxon rank-sum tests with Bonferroni correction, with a significance threshold of 0.05/496. 40 pairwise distances reached thresholds of statistical significance between PD vs controls (see Online Resource 4 for details)