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. 2021 Sep 5;227(1):23–47. doi: 10.1007/s00429-021-02373-x

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© The Author(s) 2021

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Fig. 16 — Visualization of the selection templates used for bundle selection. Typically, a template consists of one defining ‘bottleneck’ sphere, which is rather tight, and two rather large spherical volumes of interest defining the rough direction of the bundle of interest. Pink spheres in the central image represent simulated activation volumes from responders in FORESEE and FORESEE II trials for treatment-resistant major depression