Table 3.
Incidence rates and hazard ratio of new-onset melanoma among patients with bullous pemphigoid (cohort study design)
| Patients with bullous pemphigoid | Controls | |
|---|---|---|
| Follow-up time, PY | 18,320.9 | 106,465.8 |
| Median follow-up time, years (range) | 3.49 (0.00–17.64) | 4.66 (0.00–17.85) |
| Number of events of melanoma | 26 | 123 |
| Incidence rate/1000 PY | 1.42 | 1.16 |
| 95% CI | 0.95–2.05 | 0.96–1.37 |
| HR (95% CI) | P value | |
|---|---|---|
| Crude | 1.18 (0.77–1.82) | 0.447 |
| Adjusteda | 1.13 (0.73–1.74) | 0.587 |
| Sensitivity analysisb | ||
| Crude | 1.07 (0.69–1.66) | 0.768 |
| Adjusteda | 1.06 (0.67–1.65) | 0.809 |
HR hazard ratio, CI confidence interval, PY person-year
aFollowing the adjustment for age, sex, ethnicity, socioeconomic status, comorbidities, PD-1/PDL-1 exposure, healthcare utilization, and Parkinson diseases
bSensitivity analysis included only bullous pemphigoid patients under prolonged “bullous pemphigoid-related treatments”
Bold: significant value