Table 2.

Gene-metabolite pairs of newly identified eGFR-associated metabolites at previously reported loci from GWAS of eGFR

eGFR associated gene/loci	Newly identified eGFR-associated metabolites in this study
ABCC1	cys-gly, oxidized
ACSM2A	indoleacetylglutamine
ALMS1, NAT8	N-acetylhistidine, N-acetylphenylalanine, 2-hydroxyoctanoate, N-acetyl-1-methylhistidine, methionine sulfone, N-delta-acetylornithine
BC032469, SLC6A19	methionine sulfone
CPS1	N-acetylglycine, 3-methylglutaconate, 3-methylglutarylcarnitine(2), gamma-glutamylglycine, isobutyrylglycine, isovalerylglycine
DMGDH	dimethylglycine
DPEP1	cys-gly-,oxidized
FBXL20	methionine sulfone
IGF2R	acisoga
LHPP	dihydroorotate
PLA2G15	N6,N6,N6-trimethyllysine
SLC22A1	Acisoga, suberoylcarnitine (C8-DC)
SLC25A45	N6,N6,N6-trimethyllysine
SLC6A13	3-aminoisobutyrate, imidazole lactate
TPRKB	N-acetyl-1-methylhistidine