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. 2022 Jan 7;12:53. doi: 10.1038/s41598-021-03990-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Phylogenetic tree of the 40 complete ZIKV strains used for obtaining the consensus sequence (A). (B) Polyprotein of the ZIKV from the Brazilian consensus sequence. The ZIKV genome codes for seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B and NS5) and four structural proteins (Capsid protein C, Protein prM, ER anchor for capsid protein C and Envelope protein E). Protein prM is further digested into Peptide pr and Small envelope protein M. ER anchor for capsid protein C is removed by serine protease NS3. The consensus sequence was obtained from 40 complete Brazilian sequences deposited on NCBI.