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. 2022 Jan 7;12:53. doi: 10.1038/s41598-021-03990-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Secondary structure of the vaccine protein alone (A) and in association with adjuvants (B–E). Helices, coils and beta-sheets are specified in the legend, to note: alpha helix in red, 3-helix in magenta, 5-helix (pi helix) in orange, extended strand in beta ladder in blue, isolated beta bridge in yellow, hydrogen bonded turn in green, bend in black and coil in gray. ZIKVac + Flagellin (B), 50S ribosomal (C), HBH (D), RS09 (E).