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. 2021 Dec 3;53(12):1866–1876. doi: 10.1038/s12276-021-00704-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a–c Blood pressure GWAS-related genes enriched in ECs (a), SMCs (b), and fibroblasts (c). Mean expression values of the genes calculated in each cluster. Each row is a gene, and each column represents a single cell type. d Differentially expressed gene (DEG) counts between the hypertension and control groups in each cluster (blue, downregulated genes; red, upregulated genes). e DEGs identified as blood pressure GWAS-related genes according to cell cluster. f Heatmap showing differences in the average expression of candidate genes, (e) between hypertension and control groups according to cell cluster. A higher row-scaled mean expression score indicates increased gene expression in hypertension.