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. 2022 Jan 1;18(2):522–535. doi: 10.7150/ijbs.67556

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Identification of FAM83A-AS1 as a metabolism-related lncRNA in LUAD patients. (a) Experimental scheme for identifying FAM83A-AS1 facilitated tumor proliferation and the migration via the HIF-1α/ glycolysis axis in lung adenocarcinoma. (b) The scatter plot showing the distribution of Glycolysis score (x-axis) and OXPHOS score (y-axis) in LUAD patients. Patients were assigned to four metabolic subgroups according to the median value of the two scores. (c) Heatmap of differentially expressed genes between high-glycolysis & low-OXPHOS and low-glycolysis & high-OXPHOS groups. (d) The association between the expression of FAM83A-AS1 and energy-related metabolic pathways (glycolysis and OXPHOS pathways). (e) GSVA analysis of the hallmark pathways between low FAM83A-AS1 expression group (≤median expression level across all samples) and high FAM83A-AS1 expression group (>median expression level across all samples) in LUAD patients. (f) Differential expressed genes between the LUAD and the normal lung group were shown in a volcano plot. (g) The association between the expression of FAM83A-AS1 and stemness scores. (h) Kaplan-Meyer plot of OS (up) and DFS (down) in TCGA with high or low expression group of FAM83A-AS1.