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. 2022 Jan 1;18(2):522–535. doi: 10.7150/ijbs.67556

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LncRNA FAM83A-AS1 inhibits HIF-1α degradation by obstructing the interaction of HIF-1α with VHL. (a) Immunoprecipitation of anti-HIF1A and anti-VHL in hypoxia treated A549 and H358 cells knocking down FAM83A-AS1. (b) The ubiquitination level of HIF1A in hypoxia conditions of FAM83A-AS1 knockdown and control A549 and H358 cells. (c) The HIF1A expression level was analyzed by western blotting in FAM83A-AS1 knockdown and control LUAD cells after treated with proteasome inhibitor MG132 (10μM). (d) The HIF1A expression level was analyzed by western blotting in FAM83A-AS1 knockdown and control LUAD cells after treated with 25 μM CHX for indicated time periods under normoxic conditions.