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. 2022 Jan 1;18(2):522–535. doi: 10.7150/ijbs.67556

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The effect of LncRNA FAM83A-AS1 on migration and invasion of LUAD cells is regulated by HIF1A and knockdown LncRNA FAM83A-AS1 inhibits tumor growth and suppresses the expression of HIF-1α and glycolysis-related genes in vivo. (a) Wound-healing scratch assays of FAM83A-AS1 knockdown and control LUAD cells and FAM83A-AS1 knockdown cells transfected with the mutated HIF-1α plasmid under hypoxic conditions. (b) Tumor volume size of tumors in subcutaneous mouse model which injected FAM83A-AS1 knockdown and control LUAD cells. (c) Immunohistochemistry of glycolysis-related genes and HIF1A expressed in tumors from subcutaneous mouse model.