Figure 1.

RocA increases NK cell infiltration in NSCLC. LLC cells were subcutaneously inoculated onto the upper back of C57BL6 mice on day 0, and 1 mg/kg of RocA was administered by i.p. injection every 2 days from day 3. Mice were sacrificed on day 21, and tumors were excised. The proportion of NK cells in tumors were analyzed by flow-cytometry (A-B). Tumor tissues were stained with anti-NKp46 antibody and DAPI (C), and the NKp46⁺ NK cells were quantified in tumor tissues (D). The proportion of NK cells in spleens in LLC tumor-bearing mice (E) and normal mice without LLC tumor (F) were analyzed by flow-cytometry.