Skip to main content
. 2022 Jan 1;18(2):742–759. doi: 10.7150/ijbs.68724

Figure 1.

Figure 1

Schematic of PXR' functional domains contain DNA binding domain, hinge region, and ligand binding domain. Xenobiotics (including agonist and antagonist) bind to the ligand binding domain, and then PXR forms a heterodimer with RXRα and translocate to the nucleus, recognizing the consensus sequence on the promoter region of target genes to initiate transcriptional regulation of CYP450 phase I, II, III enzymes. Antagonists can be used to overcome chemoresistance in lab while applied in clinic with caution.