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. 2022 Jan 1;18(2):742–759. doi: 10.7150/ijbs.68724

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(A). Important PXR SNPs on exons and their functions. (B). The DBD region of PXR contains a bidirectional nuclear localization sequence (NLS) and zinc finger I (CX2CX13CX2C) and zinc finger II (CX6CX9CX2C) in DBD domain, which is quite similar with that of PPARγ. In contrast, PPARγ has zinc finger I (CX2CX13CX2C) and zinc finger II (CX3CX9CX2C). The RING domain of PPARγ plays E3 ligase activity to degrade NF-κB. (C). PXR protein structure can be altered by post-translational modifications. P: Phosphorylation; SU: SUMOylation; Ac: Acetylation; Ub: Ubiquitination.