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. 2022 Jan 1;18(2):717–730. doi: 10.7150/ijbs.64350

Figure 2.

Figure 2

Apoptin-induced pyroptosis by GSDME rather than GSDMD. (A) Expression of GSDMD and capase-1. HCT116 cells were treated with Ad-mock, Ad-vp3 and Ad-vt at 100 MOI, (B) microscopic imaging and (C) cleavage of GSDME were performed in the presence or absence of GSDMD knockdown. Microscopic imaging (D) and (E)cleavage of GSDME were performed in the presence or absence of GSDME knockdown. (F) Knockdown of GSDME diminished LDH release and increased viability of HCT116 cells following treatments with Ad-vp3 and Ad-vt. Data are shown as mean ± SD (*p < 0.05, **p < 0.01, ***p < 0.001)