Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 1;18(2):717–730. doi: 10.7150/ijbs.64350

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The author(s)

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

PMC Copyright notice

Apoptin-activated GSDME-dependent pyroptosis through the mitochondrial intrinsic apoptotic pathway. (A) Ad-vp3 and Ad-vt induced Tom20 accumulation and aggregation towards the nucleus. (B) HCT116 cells were treated with siRNA targeting Tom20. (C) Cleavage of GSDME was detected by western blot, (D) Knockdown of Tom20 diminished LDH release and increased viability of HCT116 cells. (E) Ad-vp3 and Ad-vt induced bax accumulation and aggregation in the nucleus. (F) HCT116 cells treated with bax siRNA targeting. (G) GSDME cleavage was detected by western blot. (H) Bax knockdown diminished LDH release and increased HCT116 cells' viability. Data are shown as mean ± SD (*p <0.05, **p <0.01, ***p <0.001)