Figure 7.

In vivo effect of apoptin in suppressing colon cancer tumor growth. HCT116 cells were subcutaneously injected into the right hind limb of nude mice (n=6). After seven days, Ad-mock, Ad-vp3 and Ad-vt were injected into the tumors every three day for 3 weeks. (A) Image of xenograft tumors, (B) tumor volume. (C) tumor weight and (D) body weight, were recorded at the indicated times. (E) Tumor metastasis was quantified using bioluminescence imaging. (F) The cleavages of PARP, GSDME, caspase-3, caspase-9, Bax release, cytochrome c, and Tom20 were detected from the tumor samples.