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. 2022 Jan 1;18(2):507–521. doi: 10.7150/ijbs.67770

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IGF2BP2 is upregulated in CC and promotes MYC expression by recognizing m⁶A modifications in MYC mRNA in CC cells. (A) Detection of IGF2BP2 and MYC expression in human CC tissues and adjacent normal tissues (n=38). (B) The expression of IGF2BP2 and MYC in 186 CC tumor tissue samples. (C, D) Correlation between IGF2BP2 and MYC expression in CC in tissue microarrays and tissue specimens. (E, F) The relative mRNA levels of METTL14, MYC, and glycolysis-related genes were determined using qRT-PCR (E) and western blot (F). (G) Me-RIP and IP assays were used to detect the m⁶A level in MYC mRNA and m⁶A expression in SiHa cells after METTL14 silencing. (H) The binding of IGF2BP2 to MYC was verified by RIP assay. (I) A ChIP assay was performed in SiHa cells using IgG and anti-MYC antibody. Each value represents the mean ± SD for triplicate samples (Student t test). ***P < 0.001, and ****p < 0.0001.