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. 2022 Jan 1;18(2):507–521. doi: 10.7150/ijbs.67770

Figure 4.

Figure 4

IGF2BP2 silencing attenuated CC cell proliferation, migration, invasion, and glycolytic capacity. (A, B) SiHa and HeLa cells were transfected with IGF2BP2-targeting siRNAs, following which mRNA and protein levels were determined by qPCR (A) and western blot (B), respectively. (C-G) The effects of IGF2BP2 silencing on the clonogenicity (C), growth (D), and proliferative (E), migratory (F), and invasive (G) abilities of SiHa and HeLa cells were evaluated. (H-K) SiHa and HeLa cells were transfected with siIGF2BP2, after which glucose uptake (H), lactate production (I), ATP levels (J), and intracellular ROS content (K) were determined. (L) The effect of knocking down IGF2BP2 on the extracellular acidification rate (ECAR) and oxygen consumption rate (OCR) in SiHa cells. Each value represents the mean ± SD of triplicate samples (Student's t test). *P < 0.05, **P < 0.01, ***P < 0.001, and ****p < 0.0001.