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. 2022 Jan 1;18(2):552–571. doi: 10.7150/ijbs.64373

Table 1.

Advanced 3D imaging technology and characterizations in imaging of small mammals.

Advanced 3D imaging technology Focus point
Whole brain scale Imaging depth Living animals Behaving animals
Light Synchrotron radiation imaging Absorption imaging
Two-photon imaging up to mm-level
Light sheet microscopy up to mm-level some methods some methods like SCAPE
Imaging system combined serial sectioning
Optical coherence tomography up to mm-level
Dynamic light scattering method up to mm-level
Acoustics Photoacoustic imaging up to cm-level
Magnetics MRI

Multimodal imaging: combined with the different techniques in the table above, or super-resolution microscopy, etc.

On the right side of the table are some separate focus points for imaging the brains of animal models, particularly rodents, including whether they are used for whole-brain imaging, the depth of imaging, and whether they are used in living or behaving animals. SCAPE: swept, confocally-aligned planar excitation. μCT: microcomputed tomography.

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