Table 1.
Advanced 3D imaging technology and characterizations in imaging of small mammals.
Advanced 3D imaging technology | Focus point | ||||
---|---|---|---|---|---|
Whole brain scale | Imaging depth | Living animals | Behaving animals | ||
Light | Synchrotron radiation imaging | √ | Absorption imaging | ||
Two-photon imaging | up to mm-level | √ | √ | ||
Light sheet microscopy | up to mm-level | some methods | some methods like SCAPE | ||
Imaging system combined serial sectioning | √ | ||||
Optical coherence tomography | up to mm-level | √ | √ | ||
Dynamic light scattering method | up to mm-level | √ | √ | ||
Acoustics | Photoacoustic imaging | up to cm-level | √ | √ | |
Magnetics | MRI | √ | √ | √ |
Multimodal imaging: combined with the different techniques in the table above, or super-resolution microscopy, etc.
On the right side of the table are some separate focus points for imaging the brains of animal models, particularly rodents, including whether they are used for whole-brain imaging, the depth of imaging, and whether they are used in living or behaving animals. SCAPE: swept, confocally-aligned planar excitation. μCT: microcomputed tomography.