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. 2022 Jan 1;18(2):693–706. doi: 10.7150/ijbs.66760

Figure 4.

Figure 4

Aβ42 species induce tau accumulation and hyperphosphorylation via the DAPK1/Pin1 pathway. (A) and (B) Immunoblot analysis and statistics of WT and DAPK1 KO primary neurons treated with LMW or HMW Aβ42 species (20 μM) for 24 h to determine the levels of DAPK1, pS71-Pin1, Pin1, total tau and tau phosphorylation at the Thr231, Ser262 and Ser396 residues. β-actin was used as an internal control. Data are expressed as the mean ± SD (*p<0.05, **p<0.01, ***p<0.001, ****p<0.0001, ns, not significant).