Over-expression of LHPP inhibited cell proliferation, migration and invasion in OSCC cells (A, B) Cell viability of SCC15 and SCC25 in NC, Vector, OE-LHPP groups cells for 24, 48 and 72 hours. (C) EdU assay of cell proliferation of SCC15 and SCC25 cells over-expressed LHPP or not for 24h. (D, E) The colony formation assay of SCC15 and SCC25 in NC, Vector, OE-LHPP groups for 14 days. (F, G) Transwell analysis for invasion of SCC15 for 24 h and SCC25 cells for 12 h. (H, I) RT-PCR analysis of snail, MMP2, N-cadherin and E-cadherin in the NC, Vector and OE-LHPP groups of SCC15 and SCC25. (J, K) The wound healing detection of SCC15 for 24, 48, and 72 hours and SCC25 cells for 12, 24, and 36 hours. *P < 0.05, **P < 0.01, ***P < 0.001.