Table 2.
Variants associated with colorectal cancer survival at P < 5 × 10–8, stratified by tumor site.
| Chromosome | Variant rsID | Alleles (risk/alternative) | RAF | RegulomeDB rank | HRa | 95% CI | P-value | Imputation quality (info score) |
|---|---|---|---|---|---|---|---|---|
| Proximal colon | ||||||||
| 12 | rs189655236 | C/T | 0.014 | 5 | 2.14 | (1.65, 2.77) | 9.19 × 10–09 | 0.85 |
| 14 | rs144717887 | G/A | 0.015 | 5 | 2.01 | (1.57, 2.58) | 3.14 × 10–08 | 0.93 |
| Distal colon | ||||||||
| 14 | rs698022 | C/T | 0.111 | 4 | 1.48 | (1.30, 1.69) | 8.47 × 10–09 | 0.93 |
Proximal colon tumor-specific analyses included 6,214 cases and distal colon tumor-specific analyses included 4,881 cases.
RAF Risk Allele Frequency, HR Hazard Ratio, CI Confidence Interval. aAdjusted for age at diagnosis, sex, genotyping batch/study, and the first five principal components of genetic ancestry.