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. 2022 Jan 7;12:286. doi: 10.1038/s41598-021-04248-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Functional analysis of the down-regulated genes identified in the meta-analysis based on FAIME algorithm. Main down-regulated pathways are indicated by colored nodes. Pathways were selected based on the FAIME scores computed using the expression of down-regulated genes (grey dots). AUC was used to evaluate the discriminatory capacity of each enriched term for a binary classification (pterygium vs. control). FAIME: Functional Analysis of Individual Microarray/RNAseq Expression; AUC: Area Under the curve.