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. 2022 Jan 7;12:138. doi: 10.1038/s41598-021-03947-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Elimination of CPNS1 decreases cardiac injury during ISC–REP. WT or CPNS1 deletion mouse hearts underwent 25 min global ischemia and 30 min reperfusion. Mouse hearts in time control groups underwent buffer perfusion without ischemia (a). ISC–REP led to decreased left ventricular developed pressure (LVDP) in both WT and deletion mice compared to time control (b). ISC–REP led to decreased coronary flow in both WT and deletion mice compared to time control (c). ISC–REP also increased the release of LDH into the coronary effluent in both WT and deletion compared to time control (d). However, LDH release was decreased in CPNS1 deletion mice compared to WT during reperfusion (d). These results supported that deletion of CPNS1 decreased cardiac injury during ISC–REP. Data are expressed as mean ± SD; *p < 0.05 vs. time control; ^†p < 0.05 vs. corresponding WT.