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. 2022 Jan 7;12:138. doi: 10.1038/s41598-021-03947-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Elimination of CPNS1 decreases infarct size during ISC–REP. In this experiment, WT or CPNS1 deletion mouse hearts underwent 25 min global ischemia and 60 min reperfusion. Infarct size was determined in hearts following 60 min reperfusion using TTC staining. ISC–REP led to decreased left ventricular developed pressure (LVDP) in both WT and deletion mice compared to pre-ischemic LVDP, respectively (b). ISC–REP led to decreased coronary flow in both WT and deletion mice compared to pre-ischemic coronary flow, respectively (c). Deletion of CPNS1 decreased infarct size during ISC–REP compared to WT (d). These results further supported that deletion of CPNS1 decreased cardiac injury during ISC–REP. Data are expressed as mean ± SD; *p < 0.05 vs. time control; ^†p < 0.05 vs. corresponding WT.